Airway submucosal glands from cystic fibrosis swine suffer from abnormal ion transport across the serous acini, collecting duct, and ciliated duct

X Luan, JS Tam, S Jagadeeshan… - … of Physiology-Lung …, 2020 - journals.physiology.org
… of the fluid produced by the individual submucosal glandsCFTR-dependent gland secretion,
triggered serous acini epithelia … Acinar origin of CFTR-dependent airway submucosal gland

Neuropeptide regulation of secretion and inflammation in human airway gland serous cells

DB McMahon, RM Carey, MA Kohanski… - … Respiratory Journal, 2020 - Eur Respiratory Soc
Airway submucosal gland serous cells are sites of … defects in CFTR-dependent serous
secretion contribute to CF … Gland acini are likely significant contributors of cytokines [54]…

Secretory cells dominate airway CFTR expression and function in human airway superficial epithelia

K Okuda, H Dang, Y Kobayashi, G Carraro… - … journal of respiratory …, 2021 - atsjournals.org
… in the regulation of airway epithelial Cl − and fluid secretory rates. … Airway submucosal
glands from cystic fibrosis swine suffer from abnormal ion transport across the serous acini

Cellular and molecular architecture of submucosal glands in wild-type and cystic fibrosis pigs

W Yu, TO Moninger, AL Thurman… - Proceedings of the …, 2022 - National Acad Sciences
… SMGs secrete liquid and most of the mucus in large airways; the … To better understand the
potential role of the two acinar cell types in electrolyte and liquid secretion, we also curated a …

Early studies of airway submucosal glands

JH Widdicombe - … Journal of Physiology-Lung Cellular and …, 2019 - journals.physiology.org
Acinar origin of CFTR-dependent airway submucosal gland fluid secretion. Am J Physiol
Lung Cell Mol Physiol 292: L304–L311, 2007. doi:10.1152/ajplung.00286.2006. …

PAR-2-activated secretion by airway gland serous cells: role for CFTR and inhibition by Pseudomonas aeruginosa

DB McMahon, RM Carey… - … of Physiology-Lung …, 2021 - journals.physiology.org
… of synergistic CFTR-dependent PAR-2/VIPR secretion may … structure of an airway submucosal
gland, showing cystic … at the distal acini, which have been demonstrated to be the origin of …

[HTML][HTML] CFTR-rich ionocytes mediate chloride absorption across airway epithelia

L Lei, S Traore, GSR Ibarra, PH Karp… - The Journal of …, 2023 - Am Soc Clin Investig
… -airway epithelia and submucosal glands, thus determining … absorption and CFTR-dependent
liquid secretion. Our … CFTR within the acinus and ducts of the airway epithelium could …

Inverse regulation of secretion and inflammation in human airway gland serous cells by neuropeptides upregulated in allergy and asthma

DB McMahon, MA Kohanski, CCL Tong… - bioRxiv, 2019 - biorxiv.org
Airway submucosal gland serous cells are sites of expression … Defects in CFTR-dependent
serous cell secretion likely play … on secretion from primary human airway gland serous acinar

Pendrin mediates bicarbonate secretion and enhances CFTR function in airway surface epithelia

D Kim, J Huang, A Billet, A Abu-Arish… - … Journal of Respiratory …, 2019 - hal.science
secretion by Calu-3 cells may be appropriate for submucosal gland acinar cells, since we
detected little pendrin in glands by … Supplementary Figure 2 CFTR-dependent intracellular …

[HTML][HTML] Pro-inflammatory cytokines stimulate CFTR-dependent anion secretion in pancreatic ductal epithelium

D Angyal, TA Groeneweg, A Leung, M Desain… - Cellular & Molecular …, 2024 - Springer
Background … activity of NFκB in acinar cells, which, together with the release of damage-associated …
CFTR-mediated fluid secretion in the submucosal glands of the respiratory tract, and …